#134 - James O'Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.

 

We discuss:

• James' background and why he favors a preventative approach to cardiology [3:15];
• Understanding atherosclerosis and the misconception that it's a "plumbing problem" [10:15];
• The danger in excessive exercise—a reverse J-shaped mortality curve [21:15];
• The story of Micah True—A case study of excessive exercise [49:15];
• The best kinds of exercise for longevity—The Copenhagen City Heart Study [53:00];
• Being a more balanced athlete and finding the right exercise intensity [58:45];
• Heart rate during exercise, resting heart rate, and other important metrics [1:04:00];
• Nutrition for cardiovascular health [1:09:45];
• Important nutrients: Magnesium, potassium, calcium, sodium, and collagen [1:19:30];
• SGLT2 inhibition for diabetes, cardio-protection, and general longevity [1:24:15];
• GLP-1 agonists for weight loss and reducing cardiovascular risk [1:34:15];
• Statins—Mechanism of action, safety, and useful alternatives [1:37:25];
• A 40-year view on cardiovascular risk, and the possibility of reversing arterial calcification [1:45:45];
• Evidence for high dose EPA and DHA for the reduction of cardiovascular disease risk [1:53:30];
• The impact of omega-3, curcumin, and other compounds on mental health and dementia [1:59:00];
• James' focus beyond cardiology [2:02:15]; and
• More.

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