#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia

 

We discuss:

• How Amanda developed a passion for geriatric psychiatry [3:15];
• Defining and diagnosing dementia and Alzheimer's disease [13:30];
• Medical tests for dementia and their relationship to clinical symptoms [22:45];
• The pathology of dementia, and the role of the tau and beta-amyloid protein in Alzheimer's disease [33:15];
• The significance of ApoE genotype, and differentiating Alzheimer's disease from Lewy body dementia [43:15];
• The evolution of Alzheimer's disease prevention, care, and medications over the last 20 years [52:45];
• Psychiatric support for dementia patients (and caregivers) with depression and anxiety [1:02:45];
• Drug pipeline, clinical trials, and major challenges to overcome [1:13:45];
• Redefining Alzheimer's disease and designing effective trials [1:23:00];
• The promise of monoclonal antibody treatments for Alzheimer's disease [1:34:15];
• How we should measure outcomes in dementia trials and define "healthy aging" [1:42:30];
• How understanding dementia can reshape our life philosophy [1:53:45]; and
• More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/AmandaSmith

Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

Connect with Peter on Facebook | Twitter | Instagram.