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欢迎收听医学前沿播客，这里是科研喵，使用AI读文献，助你效率百倍。访问labcat.com.cn下载。今天的头条研究揭晓了癌症干细胞中的核胆固醇如何调节核大小和DNA损伤反应。研究者发现，脑胶质瘤干细胞核体积较小，而核胆固醇合成酶LBR的表达增加是其关键。靶向LBR能够增加核体积，减少干细胞活力，抑制肿瘤启动。此外，LBR的缺失或胆固醇水平的降低会诱导DNA双链断裂，激活P53依赖的DNA损伤反应。这一发现揭示了一个新的治疗靶点，为癌症干细胞的治疗提供了新思路。
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