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科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。
本期关注发表在《Trends in pharmacological sciences》(IF:13.9)上的重要综述"Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology"。该研究探讨了靶向细胞泛素-蛋白酶体系统的新型药物开发策略，聚焦于SUMO靶向泛素连接酶(StUbLs)系统在疾病治疗中的应用。研究发现，通过SUMO化-泛素级联反应可有效失活致癌融合蛋白，如抗癌药物三氧化二砷和氟维司群所展示的机制。更有前景的是，proximity-inducing技术可将易聚集蛋白招募至StUbL系统，有望减轻神经毒性包涵物形成。这项研究为肿瘤学和神经退行性疾病的治疗开辟了新途径，展示了重新编程SUMO-StUbL信号的巨大临床潜力。
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