3550: Signos and the Case for Seeing Your Metabolism in Real Time

What if the biggest breakthrough in weight management is not a new diet, but finally seeing how your body responds in real time?

That question sat at the center of my conversation with Sharam Fouladgar-Mercer, CEO and co-founder of Signos, a continuous glucose monitoring (CGM) and AI-powered health platform built to help people manage weight by understanding their metabolism. January is when motivation is high and the wellness noise is loud, but it is also when a lot of people realize how hard it is to stick with generic advice that does not fit real life. This episode is about why personalization matters, how metabolic signals can change the way you think about food and exercise, and what happens when health technology shifts from reporting the past to guiding the next decision.

Sharam explained how Signos pairs a CGM with an AI-driven experience that turns glucose data into practical actions. The point is not to force people into rigid rules or extreme restrictions. Instead, it is about learning how your body reacts to everyday choices, then using that feedback to reduce spikes, improve consistency, and build habits you can actually live with. We talked about simple interventions, like changing the order of foods in a meal, timing movement more intelligently, and spotting patterns that would otherwise stay invisible.

Two personal stories brought the conversation to life. Sharam shared how he lost 25 pounds while increasing his calorie intake, which challenges a lot of assumptions people carry into weight loss. He also shared a story from his family life, where his wife's deep sleep increased from roughly 20 minutes a night to around 60 minutes after focusing on glucose stability, even while total sleep time remained limited during the intense period of raising young kids. It is the kind of detail that hits home for anyone who has ever tried to make healthier choices while exhausted and stretched thin.

We also explored why FDA clearance matters for Signos and what that could mean for mainstream access. Over-the-counter availability reduces friction, can lower cost, and opens the door to broader adoption, including potential FSA and HSA eligibility. Looking ahead, Sharam shared a vision that goes beyond weight management, connecting metabolic health to the long arc of prevention and chronic conditions where insulin resistance plays a role.

If you have ever felt like you are doing all the "right" things and still not seeing results, this episode will make you rethink what "right" even means. And if you could finally see your metabolism in real time, would it change how you approach food, sleep, exercise, and the habits you want to keep this year?

Useful Links

• Connect with Sharam Fouladgar-Mercer
• Learn more about Signos
• Instagram, Facebook, X and YouTube

Thanks to our sponsors, Alcor, for supporting the show.