400 Startups Building the Post-Web Economy, with Outlier Ventures Founder Jamie Burke

Lex chats with Jamie Burke - founder of Outlier Ventures, about the current state and future of Web3, decentralized finance, and the metaverse. Jamie highlights Outlier Ventures' impressive growth, with a portfolio of around 400 startups, and discusses successful projects like IOTA and Fetch.ai. The conversation delves into the open metaverse, emphasizing the importance of infrastructure and middleware in blending physical and digital realities. Jamie also explores the transformative role of AI in the metaverse and offers practical advice for entrepreneurs navigating this rapidly evolving landscape.

 

Notable discussion points:

 

1.The “Post-Web” Is an Intent-Led Internet: Jamie Burke outlines a shift from today’s attention-based web to an intent-driven internet, powered by AI agents, Web3 infrastructure, and DePIN. In this model, agents act on user intent, radically streamlining interactions and replacing much of today’s web interface.

 

2. Web3 Will Be Run by Machines, Not People: Burke predicts that autonomous agents—not humans—will become the primary users of blockchains, making crypto “machine money.” As a result, products, brands, and processes matter less, while incentive systems and on-chain automation take center stage.

 

3. Founders Must Embrace Systems Thinking: In the Post-Web era, survival depends on designing self-optimizing systems, not just building products. Burke stresses that token engineering, incentive design, and value flow mapping will define the next generation of durable startups.

 

MENTIONED IN THE CONVERSATION

 

Topics: Web3, decentralized finance, metaverse, Open metaverse, Post web, Outlier Ventures, IOTA, Fetch.ai, accelerator program, AI, artificial intelligence, Agentic AI, agents, Web3, post-web, digital economy, blockchain technology

 

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TIMESTAMPS

 

1’18: Outlier Ventures in 2025: From IOTA to Fetch.ai, Backing the Infrastructure Behind Intelligent Web3

 

10’24: The Open Metaverse Revisited: Outlier’s Long-Game Bet on Augmented Reality, Middleware, and AI-Driven Agents

 

26’01: FThe Post-Web Era: How AI Agents, Web3 Infrastructure, and Delegation Will Redefine the Internet

 

35’57: From Attention to Intention: How AI Agents and Web3 Are Flipping the Internet on Its Head

 

49’39: Surviving the Post-Web Paradigm: Why Founders Must Shift from Startup Thinking to Systems Design

 

57’49: The channels used to connect with Jamie & learn more about Outlier Ventures

Disclaimer here — this newsletter does not provide investment advice and represents solely the views and opinions of FINTECH BLUEPRINT LTD.

Contributors: Lex, Laurence, Matt, Farhad, Mike, Daniella

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