Ancient Foes, Now Mortal Enemies, Esther 3, OT S1:E270

Esther's adoptive father Mordecai earns the wrath of Haman, the second in command of Persia because he refused to bow before anyone besides God or king. Haman's anger led to a murderous, then genocidal hatred for Mordecai and all the Jews. In this episode we learn that this conflict was over 1,000 years in the making.