Comfort Without Compromise: Phenylbutazone and Mare Fertility

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Challenging conventional wisdom in equine reproduction, this episode explores revolutionary research about phenylbutazone's impact on embryo production in mares. When previous studies claimed mares on "bute" had zero successful embryos via intracytoplasmic sperm injection (ICSI), Dr. Kristen Loncar and her team questioned these findings based on their own clinical success. Their subsequent investigation reveals surprising results with significant implications for veterinary practice and equine welfare.

Dr. Loncar walks us through the evolution of transvaginal follicle aspiration and ICSI technology, which has transformed from a last-resort procedure for problem mares to an efficient breeding method for both aging broodmares and performance horses. She explains how their research tested various phenylbutazone formulations—liquid (oral and IV) and paste—finding no significant decrease in blastocyst rates compared to control groups. This groundbreaking discovery resolves a critical ethical dilemma: veterinarians no longer need to choose between managing a mare's pain and pursuing reproductive success.

The conversation delves into fascinating aspects of equine reproductive medicine, future research directions, and the potential role of AI in analyzing embryo development. Whether you're a practicing veterinarian, breeder, or horse owner, this episode provides essential insights into managing aging or arthritic mares while preserving their reproductive potential. Listen now to discover how science is enhancing both quality of life and reproductive options for horses under veterinary care.

JAVMA article: https://doi.org/10.2460/javma.25.04.0285

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