Eliminating the ADVERSE REACTIONS of Medication

0:00Spring is here, and the shopping list is long. Time to make a lows run. Buy three bags, get three free. Stay green, one cubic foot garden soil. Plus, right now, members can earn four times the points on an eligible purchase. Start spring off strong with these deals and more. Our best lineup is here at Loads. Valid for $3.25, while supplies last. Soil offer excludes a last-gen Hawaii. Loads to program subject to terms and conditions. See Loads.com slash terms for details. Subject to change, point booster subject to exclusions, and more terms apply. One time only offer. You know you need fiber for a healthy gut, but do you actually know how to get it? Quakers have been serving up fiber since 1877, with over 100 great tasting good source of fiber options to choose from. Whether you like old-fashioned oats, instant oatmeal, granola, or oatmeal squares. Quaker makes it delicious. Mmm, so good. Get your fiber with Quaker. Shop Quaker's good source of fiber products at a store near you. Now, this information is very, very important

1:01if you are on medications. If you know of someone on medications, send them this video, because I'm gonna show you how to greatly reduce the side effects from medication. Now, one primary reason why a lot of people have side effects from medication has to do with something in your liver. It's a certain group of enzymes that help break down certain medications and toxins as well. And if that enzyme system is not working, not only are you gonna experience more side effects, but the medication could also not be as effective as it should. Now, of course you already know this, but I'm all about giving people alternatives to medication, but there's certain people that need to be on medication. And it's a really good thing to minimize the side effects. And then at the end of this, I'm gonna give you a download that you can give your medical doctor to help them look at a potential DNA problem

2:02that you might have that can greatly alter the type of medications that you're given. And so I will talk about that at the end. But let's first just talk about what is an enzyme? An enzyme is a protein that speeds up the chemical reaction in your body millions of times faster than if that enzyme wasn't working. The great majority of medications work by inhibiting certain enzymes. For example, like an ACE inhibitor, which inhibits this ACE enzyme that affects the blood pressure, like aspirin inhibits something called cox enzymes that relate to inflammation. And so enzymes speed up the reaction, but what's really interesting about enzymes is they don't seem to use their own energy in this work that they do. In other words, they can keep being recycled and they seem to be very magical in that way.

3:02The other thing about enzymes in order to make them work is they need helper molecules. They need, it's called cofactors or co-enzymes. And those are basically vitamins and minerals. And so now you know very simply why we need vitamins and minerals to allow these enzymes to work in our body. And we have millions and millions and millions of different enzymes in the body that create all sorts of different effects. But the primary enzymes I'm gonna talk about today are called the phase one, phase two enzymes. Now these are families of enzymes. They're groups of enzymes. They're not just one enzyme. And the phase one enzymes in your liver are called cytochrome P450 enzymes. Again, there's a family of them. And if there's any problem with this enzyme, you're not gonna get the breakdown or at least the start the breakdown of this drug or toxin or whatever's trying to be broken down. And then when you get into phase two,

4:05which works with phase one, you have other enzyme groups called glutathione enzymes. So you have both of these working together to take a poison, I'm sorry, medication and dismantle it and then turn it into a harmless water soluble particle that can be eliminated through the urine or the sweat or the bowel. And this doesn't just have to do with medication breakdown. This has a lot to do with pesticides, herbicides, fungicides, benzene from petroleum products that you're exposed to, procarcinogens, which are cancer causing things, smoke, the chemicals in smoke, alcohol, estrogen. So this enzyme system is very, very important. Not necessarily just to reduce the side effects, but also the effectiveness of a drug, but also to prevent cancer because a lot of these medications or toxins that you're exposed to, if they're not fully broken down, they can build up in the body and accumulate and create toxicity

5:08and increase your risk for cancer and other problems. Why am I talking about this right now? Well, recently I'm doing a deep dive into genetics and it's a fascinating topic and there are certain problems that go on with your DNA and your genes that can end up causing a problem with your ability to detoxify one section that I'm studying right now is all about the detoxification genes. And a big one, which is a common problem is a mutation of this cytochrome P450 enzyme system. There's over 2,000 different mutations that you can have with this one gene and it can lead to a lot of problems. So if you get your DNA tested and you find this being a problem, then you need to work harder on these detoxification enzymes and it could be the reason why you are experiencing unnecessary. XMA is unpredictable, but you can flare less with EVGLES, so once monthly treatment for moderate to severe XMA. After an initial four-month or longer dosing phase,

6:09about four and 10 people taking EVGLES, achieved itch relief and glare are almost glare skin at 16 weeks. And most of those people maintain skin that's still more glare at one year with monthly dosing. Hempless, Liberty Kizumap, LBKZ, a 250 milligram per two-milliliter injection is a prescription medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds or 40 kilograms with moderate to severe XMA. Also called atopic dermatitis that is not well controlled with prescription therapies used on the skin or topicals or who cannot use topical therapies. EVGLES can be used with or without topical corticosteroids. Don't use if you're allergic to EVGLES. A allergic reaction can occur that can be severe. Eye problems can occur. Tell your doctor if you have new or worsening eye problems. You should not receive a live vaccine when treated with EVGLES. Before starting EVGLES, tell your doctor if you have a parasitic infection. Ask your doctor about EVGLES and visit EVGLES.Lily.com or call 1-800-LilyRX or 1-800-545-5979. This is Andrew Huberman, host of the Huberman Lab podcast. I'm excited to share that the performance eyewear company Roca and I have teamed up to create a pair of red lens glasses. These are meant to be worn in the evening

7:10after the sun goes down. They filter out short wavelength light that comes from screens and from LED lights, which are the two most common indoor lights nowadays. I want to emphasize that these are not traditional blue blockers. Yes, they filter out blue light, but they also filter out all the other wavelengths of light that can suppress your melatonin and other hormones which can degrade your sleep. By wearing these glasses in the evening, I find it much easier to wind down at night and it makes the transition into sleep greatly improved. If you would like to try these red lens wind-down glasses, simply go to roca.com. That's roca.com and enter the code Huberman to save 20% off your first order. Again, that's roca.com and enter the code Huberman at checkout. Sorry, side effects from your medication in general. So number one, you can have DNA mutations with these enzymes. Okay, that's number one. Number two, you can have liver problems. Let's see your liver is fatty or let's say it's inflamed or let's say you have scar tissue as in cirrhosis. This can decrease the function of these,

8:10this phase one, phase two detoxification. Also, if you're consuming grapefruit, which is an inhibitor of this Enzyme, the Cetacrome P450, that can be a problem because what happens now, that medication that you take starts to accumulate and it can create a much bigger effect than it should. And then also, certain medications can inhibit that Enzyme too, like Warfarin and it depressants and even statins. So, your doctor needs to be aware of this. A lot of this detoxification can then lead to inflammation. And this is why even like the omega-3 fatty acids, like from the fish oils or the cauliflower oil, let our anti-inflammatory that support the heart. And even some of the omega-6 fatty acids that create inflammation also work with this enzyme. So, again, if there's a problem with this enzyme or your liver, you might not get the full benefit of these fish oils or cauliflower oil when you're taking them.

9:10You still feel inflamed. So, the question is, how do we speed up this phase one, phase two detoxification system? Well, you're in luck because certain vegetables help to trigger this enzyme system. So, in other words, it causes these enzymes just to work better in your body, which is kind of like an unswitch. So, you have the cruciferous family of vegetables and you also have the allium, which is the garlic and onion. Now, if you do the cruciferous sprouts, like broccoli sprouts that are very high in sulfurophane, that would be a really big trigger. You can also do a supplement called Dim, which is a concentrated form of cruciferous, which is a potent stimulator of phase one, phase two detoxification as well. Now, the other really cool thing, which is pretty inexpensive, is you just do fasting. Fasting is a potent stimulator of the phase one, phase two detoxification. You wouldn't think that fasting could do that, but when you don't eat, you start to detoxify in a good way.

10:13And it's pretty inexpensive. Now, number three, the obvious one is reduce the exposure of these chemicals and toxins and poisons and get with your doctor. And maybe there's alternative versions of some of the medications that you're on so you can take maybe natural versions of these medications. And then, number four, is just strengthening your liver. And one big way to do that is to get the fat out of the liver and the way that I recommend to do that is to get on a healthy version of the ketogenic diet, okay? And then there's a really good supplement called Milk Thistle. You can take that, that strengthens the liver. And then there's also herbal things that you can take, curcumin, green tea, and garlic, like I mentioned with the allium vegetables. And for more information and how to target the liver directly and get that fat out the liver, I should really check out this video right here. Jackson Hewitt has a great tax prep deal, $149 or less.

11:15Missing out is like ignoring the check engine light in your car, you regret it. Seriously, the price is only $149 or less, no matter how complicated, so don't wait. Like when you get a password expired today alert or you're shopping online and there's only one item left, it's like your taxes are in the cart, just complete the purchase. Hurry, this deal for $149 or less is like your phone at 1%. It's about to power down. Limited time offer for new clients on federal returns, participating locations only, terms of Jackson Hewitt.com, slash $149. Rinse knows that greatness takes time, but soda's laundry. So Rinse will take your laundry and hand-deliver it to your door, expertly cleaned. And you can take the time pursuing your passions. Time one spent sorting and waiting, folding and queuing, now spent challenging and innovating and pushing your way to greatness. So pick up the Irish flute or those calligraphy pens or that daunting beef Wellington recipe card and leave the laundry to us. Rinse, it's time to be great.