Episode #104 Better than BPC-157? Let's talk about KPV! The major benefits of KPV, gut health, fighting inflammation, skin and wound healing, immune function support, synergy with BPC-157 and more!!

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Now listen to this.

It actually down regulates oxidative stress pathways.

I believe it is stronger, it does more.

This is like the next generation BPC that everybody is going to be wanting to use it.

I will never, ever put doubt on that.

Better than BPC 157, really, is that possible?

Something that is going to be more popular and more widely used, oh I don't know because

everybody under the sun wants to talk about BPC 157 and rightfully so because it is tremendous.

But there are other confounds out there that do some amazing things and I'm going to

talk to you about what I believe is the most underrated peptide in existence.

It is at the top of my list of new favorites and that is KPV.

Now I am Dylan Jamelli.

I am your resident expert when it comes to hormones peptides and biohacking in general.

And I listen.

I am only smart because I hang around smart people and I just have years of experience

and study and a lot of on hand coaching, seeing how things work and I have learned from

some of the best people around the world, especially when it comes to peptides.

So I am going to get into some things here talking about KPV.

Now most people have kind of learned about KPV through the CLOW stack because at first

it was the GLOW stack which we know is BPC 157, TB500 and GHKCU copper peptide.

But then we started to see the CLOW stack and I believe it was called CLOW because we added

the KPV to it.

I think that is the shining star.

I will not come out here and say that it is better than BPC 157 but it is extremely

synergistic with it because look BPC is a phenomenal.

It is body protective compound.

It is one of the most well known most reputable, if not the most reputable peptide and most

popular in existence and rightfully so I will never ever put doubt on that.

However, KPV works synergistically with it extremely well.

So what I am going to do is give you an explanation here on KPV, what it is, what it does

why I love it so much and then we are going to talk about the synergy between the two.

So it is a tripeptide of three amino acids.

So we are talking about lysine, proline and baleine.

Now it is a fragment of a larger molecule and that is known as AMSH and that plays a central

role in immune function, inflammation control and melanogenesis.

One of the things that makes KPV a standout and really unique is that it retains all

the anti-inflammatory benefits of an AMSH without stimulating melanocyte receptors.

So that makes it really safe for systemic use without affecting pigmentation or hormone

levels in any way shape or form.

Now I am going to run down some of the benefits of KPV.

Number one is that it has really, really strong anti-inflammatory effects.

Now it has been shown to suppress pro-inflammatory cytokines which are implicated in numerous

chronic conditions and this makes it really valuable in controlling systemic and localized

inflammation without suppressing the immune system entirely like steroids would.

Number two and this is one of the things that I think it is most well known for and one

of the things that I absolutely love about it.

It supports gut healing as well as barrier function.

So one of the most exciting aspects of KPV's application is in healing the intestinal

mucosal barrier.

Now it enhances epithelial cell regeneration and it reduces inflammatory signaling.

It promotes tight junction integrity and this is crucial for yes addressing leaky gut syndrome

and other food sensitivities, IBD, etc.

Number three we are talking about a balance of immune activity rather than suppressing

immunity KPV modulates it.

So it helps calm an overactive immune response without compromising defense mechanisms which

makes it really ideal for autoimmune diseases, histamine intolerance, mast cell activation

syndrome also known as MCAS, gastrointestinal disorders so it does a ton.

What else does it do?

It improves skin conditions.

It has topical and systemic applications in improving psoriasis, eczema, inflammatory

acne and these effects are due to its suppression of inflammatory mediators as well as restoration

of skin barrier function.

What else?

It protects against oxidative stress.

Now listen to this.

It actually down regulates oxidative stress pathways and reduces reactive oxygen species

and what does that do?

It gives protection at the cellular level and it improves tissue healing especially in

the gut, the brain and our skin.

Here's one of my favorite aspects aside from the gut health that we talked about.

It supports neurological health.

You guys have heard me talk a ton now recently about the mind body connection.

You know about my studies in neuroscience.

So what does it do?

It reduces neuro inflammation and oxidative stress.

So we're talking about helping with brain fog, migraines, neurodegenerative concerns,

mood disorders that are tied to inflammation.

Now, let's talk about mechanism of action here.

How does it work?

It works by targeting several different pathways simultaneously.

I'm going to throw some stuff out here at you.

So it inhibits NFKB activation and that is a central pro-inflammatory transcription factor.

Now it suppresses IL6, TNFA and MCP1.

These are common inflammatory cytokines and it also restores tight junction proteins

which then reduces gut permeability.

It also calms mass cells and modulating allergic and autoimmune responses and it down regulates

TLR4 which reduces in a immune over activation and its safety and systemic tolerance make

it a very unique versatile peptide in the anti-inflammatory toolkit.

It's often described as an anti-inflammatory peptide.

As you can see, but inflammation is only one piece of recovery.

Reducing inflammation helps, but healing.

This depends on tissue signaling, circulation and repair capacity.

The injury joint and recovery blueprint explains where peptides like KPV fit and why controlling

inflammation unknown isn't enough.

You got to get the joint and injury recovery blueprint and read that and learn about it.

Now who should consider KPV peptide therapy?

It's ideal for people that have gastrointestinal issues, inflammation, Crohn's ulcerative colitis,

IBS, leaky gut, esophageitis, post-antibiotic gut dysbiosis, autoimmune and inflammatory

condition psoriasis, rheumatoid arthritis, Hashimoto's, Lupus, histobene intolerance,

MCAS.

I mean there's a long list of things.

It helps stabilize mass cells like I said.

Reduce histamine, mediated symptoms and restore gut lining integrity.

Skin conditions like I talked about acne, eczema, chronic dermatitis and it also accelerates

tissue healing and it dampens post trauma inflammation particularly in soft tissues and

mucosal linings.

BPC157 is largely focused on tissue repair and regeneration while KPV is a specialized

anti-inflammatory and immune modulating peptide.

So they're often used together to create a very comprehensive healing protocol that addresses

both physical injury and inflammation.

So just real quick to touch on BPC157.

BPC157 works by increasing angiogenesis which is new blood vessel growth.

It improves circulation to our injured areas and accelerates cell regeneration so it's

best for injuries like your tendons, ligaments, muscles, post surgical recovery, chronic gut

issues like ulcers and joint pain and it's known for its ability to promote healing,

even in harsh environments like the digestive tract.

Now I covered everything there is to know about KPV.

What are we going to do here with these?

Are we going to stack them or are we going to use them separately?

You can use them separately just fine.

I assure you they do extremely well on their own but when they use together they offer

a very synergistic approach to healing, comprehensive gut health because BPC repairs the structural

damage while KPV reduces the inflammation that caused the damage.

Then let's look at some advanced recovery.

So BPC accelerates tissue repair and KPV manages the inflammatory response so that reduces

the overall recovery time.

So you see it's like peanut butter and jelly and that's one of the things I love is that

while used on their own some of these are absolutely phenomenal but when you start

stacking them together and you see the synergy and you see how they work hand in hand,

it is on an entirely different level so KPV to me it is the most underrated peptide right now

it's but more and more people are starting to get up to speed on it and understand to me

this is like the next generation BPC that everybody's going to be wanting to use it especially

with all of the understanding it could turn on leaky gut and all of these other conditions

that I talked about and I truly believe that I know that everybody uses BPC and TB 500 as

like their master stack I think KPV will replace TB 500 I believe it is stronger it does more

TB 500 works extremely well with BPC 157 no doubt there's no doubt there whatsoever I've

been a huge proponent of that but if you had to pick between all four in the closed stack and

as much as I love GHKCU the first two I would pick would be BPC 157 and KPV all day long

that's the synopsis there is it better than BPC 157 that's arguable considering that it addresses

something that is so prevalent of a problem and we're talking about leaky gut I believe that is

one of the biggest problems and biggest culprits in the degradation of overall health and as much

as as necessary as BPC is for injury healing and prevention I think leaky gut is a much bigger problem

I think there's a fair argument there in KPV's favor but to each their own I'm only here to give

facts so that being said stay tuned for playmorecom Dylan Jamelli signing off