Examines the ethical challenges and issues surrounding innovation in medical technology and practice. The sources originate from discussions at a Lasker Forum and explore the difficult distinction between experimental research and routine medical care, especially when new techniques are introduced. Case studies in off-label drug use, innovative surgery, assisted reproduction, and neuroimaging are used to illustrate the ethical dilemmas. A central theme is the balance between promoting medical progress and ensuring patient safety through appropriate oversight, informed consent, and the professional duty to learn and educate others.