Pioneering Protocol-Based Solutions for Skin Longevity Featuring 111SKIN Founders Dr. Yannis Alexandrides and Eva Alexandridis

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In this episode of Skin Anarchy, Dr. Ekta Yadav is joined by Dr. Yannis Alexandrides and Eva Alexandridis, the husband-and-wife team behind 111 Harley St. and 111SKIN, for a candid, science-forward conversation on regenerative aesthetics, protocol-based skincare, and what longevity really looks like when it’s rooted in medicine—not marketing.

111SKIN didn’t start as a beauty brand. It began in the operating room. Dr. Alexandrides shares how his work in facial plastic surgery led him to develop skincare that could support faster healing and stronger outcomes after surgery—when nothing on the market met his clinical standards. What surprised him most wasn’t just improved recovery, but the long-term transformation in skin quality patients experienced once healing was complete. That insight became the blueprint for translating surgical-grade science into daily care.

A central theme of the episode is maintenance. Procedures, Dr. Alexandrides explains, are only as successful as the skin’s baseline health. Eva expands on this philosophy, emphasizing that 111SKIN was never about instant fixes—it was about training skin to behave better over time. Longevity, in their view, is built through consistency, restraint, and respect for biology.

The conversation also dives into the brand’s measured approach to advanced technologies like exosomes—used as targeted protocols rather than trends—and the broader shift in aesthetics toward regeneration over replacement. From deep plane techniques to micrografting, Dr. Alexandrides explains why modern plastic surgery is moving away from excess and toward preservation.

Throughout the episode, one message remains clear: longevity aesthetics aren’t about changing who you are—they’re about supporting skin health so you can look like yourself, for longer.

Listen to the full episode of Skin Anarchy to hear Dr. Yannis Alexandrides and Eva Alexandridis unpack the science behind 111SKIN, regenerative skincare, and the future of evidence-based aesthetic care.

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