The DNA way: Unlock the secrets of your genes to reverse disease, slow aging, and achieve optimal wellness

0:30One of the most pressing and unasked questions in public health is, why do people's response so differently to the same medication, the same interventions, and the same supplements? Today's guest, the author of the DNA way will discuss how your DNA, your own personal blueprint, can show the variations in your immune system, your detox capacity, and your personal inflammatory response. There is no universal biological reaction to anything that you put in your body. Let's find out why. Welcome to the 10-Penny Files, everyone. I'm your host, Dr. Sherry Tenpenny. But matters to your body, your freedom, or your future, we talk about it here. There's a new topic every day. So please join us daily. I want to introduce you to topics you've never heard of before, and especially controversial topics. Things that will make you think and stretch your boundaries. We talk about politics, history, astronomy, fitness, food, and farming.

1:30And once a week, we talk about health and health policy, and we talk to pastors and authors about biblical principles. Join me here daily, Monday through Friday at 3 p.m. Eastern time, on the 10-Penny Files, where we can hear from voices that have been silenced or censored or ignored. Before we begin today's episode, I want to invite everyone to come to a 10-Penny Prime member. You can find out more about that and hopefully join our cause at primemembership.dr10penny.com. And hopefully you will support our work and support us. One last thing, welcome to all of our regular people who come and join us here regularly, and to all the new people that have just found our show, we're very grateful to have you here too. Now with that, let's get started. The day's conversation is with Kashif Khan about the book The DNA Way. Lock the secrets of your genes and reverse disease, slow aging, and achieve optimal wellness and action plan to help you live your life best, which starts with understanding your genetic

2:32makeup. Kash, welcome so much to the 10-Penny Files. Thank you so much for joining us here today. Such a pleasure. Excited about the conversation. As the co-founder of the DNA company, your book is about the importance of your personal DNA blueprint, but you start out the book by saying, quote, a person's DNA is not their destiny. What does that really mean? So we have this, we've been taught because genetic research is very much a disease centric, because if you think about who pays for the research, the goal is pill per meal, right? So they're looking for gene variants and pathways that directly equal a disease, but that's not where chronic disease comes from. The number of these is caused over many years. And so when you look at your DNA, what it's telling you is instructions. Here's how every cell and every job in your body is happening based on an instruction. Sometimes an instruction is poor, and so your choices, environment, nutrition, and lifestyle

3:32may be burdensome to you when, in fact, for other people, they're not. And so this thing about your genes, not being your destiny, I can tell you which biological processes are subopful. You don't do a good job detoxifying chemicals. You don't do a good job of removing estrogen metabolites for your body and so on and so on and so on. The threat comes when you make choices that are not aligned to that genetic profile. You can very much show, make choices that are aligned and then also same exact genetic profile, two different outcomes. That's pretty, that's pretty amazing that you can determine that much specificity from a DNA test. Yeah, I would say the core pathways are, no, there's 22,000 genes, I would say most of those noise, right? There's really about 100 genes that matter for everyday functional health, the things that are always happening. And this is another failure of genetics. Genetics is, let's look for a gene that's a disease cause. Functional genomics is, let's look for the systems and pathways that are always on that

4:35are not expressed on and off as we're told the way genes were, a disease works. You're always making hormones, you're always metabolizing food, you're always thinking, you're always perceiving your stimulus through neurochemicals in your mind. That stuff never stops. And so the everyday functional activity is all we need to focus on. And if you deal with that, life extension and chronic disease risk is really back in control because it's the choices you make on top of that and equal it. You know, Obama in 2015 pointed out, he pointed out amazingly, that the medical treatment is primarily a one size fits all for the average patient, blood pressure, cholesterol, weight, all these different things. By contrast, you described that your DNA is an innovative approach to precision medicine. How does DNA testing help you design a specific program for the individual? Well, it goes by first of all, not assuming or believing that the symptom that you have

5:38is the problem we're trying to solve. So we've been taught that the right path to treatment is diagnosed and prescribed. Step one is I have to give it a name as a clinician. And then after I give it a name, that allows me to prescribe. So the ultimate goal was prescribe or surgery. So nowhere in there are we asking why? We're asking what? What is this called? As opposed to where did it come from? And so when we get into personalized treatment, that's only possible if we start thinking about what treatment is differently to begin with. And then you don't get into the averages. You get into end of one. What is my answer? The diagnosis and prescribed path is very much designed around one size fits all. This symptom doesn't matter who you are or why you happen or where you live or what you ate. Here's how we treat this symptom. The functional path is very much your own unique personalized answer. We're trying to figure out what changed here. Is it in your gut microbiome? Is it a hormone issue?

6:39Is it a toxic burden issue? Is there an immune issue? Lime disease? Epstein? Bar what's going on? And when you start to look at those pieces, the actual drivers, and you realize not only was it the source of that symptom, but potentially others down the road? They're all the same. They're all included in inflammation, dismodulated immune system, and low cellular energy. Those are actually how you manage health. Increase cellular energy, manage your immune system, and don't have inflammation. And so when we look at the genome, what we can see is where does the inflammation come from? What would break your immune system? Why is your mitochondria struggling? And if we start to fix those things, you don't need to isolate every separate symptom and disease. You've already dealt with the central hub that caused all of them. You know, that's really true. And I've said for many, many years that there's only two things that cause illness, only two, an excess of something or a deficiency of something. You know, an excess of too much toxicity, a toxic body, a toxic environment, a toxic relationship,

7:43you know, too much excess of bad food. I mean, excess weight, all those different things. And so there's an excess of something or there's a deficiency of something like a nutrient, like exercise, like love in your life, like there's a deficiency of something. You know, the role seriously of the clinician should be what is the excess that you need to get rid of and what is the deficiency that you need to replace. But medicine has made it so much more complicated than that. And like you said, they need to label it. And Kirkgaard said, what, two, two hundred years ago, once you label me, you negate me. So once you have a label in nothing else counts, we don't look at anything else. Now that you have your diagnosis of fibromyalgia, you know, nothing else matters, you know, because that's your, that's your label. And we're not, we're not defined by that label and we can change it. In fact, you had five chronic diseases that you were dealing with before you did your own DNA testing.

8:44What, what was that all about? And what, how did that doing that testing help you identify the root cause of what was going on in your own body? So I was 38 years old and I had never been sick. Health was not a concern. And then all of a sudden, I had Xima so bad that I literally couldn't open my left eye. It was sealed, shut, mental, mental, whole left side of my face. I either had white steroid cream everywhere or red patchy skin, right? I had psoriasis, autoimmunity, all over migraines. The migraines are actually what drove me to seek help. Everything else I fought through it, right? Got issues, reflux, depression, didn't want to get out of bed. Let's just kept growing. So migraines sent me to the doctor. My friend was a clinician here in Toronto where I live. MRI, CAT scan, there's nothing wrong with your brain, right? So I go, why is it hurt? So I kept asking all these doctors, what did I do? Because I didn't have any of this stuff. And now all of a sudden I have all of it.

9:45And in my mind, I was picturing like a movie, like Chernobyl. Like I touched some toxic waste or something happened, right? And I couldn't get that answer. And that was the first time I realized what alopathic health care is. It's diagnosed and prescribed. And that's it. And as long as I'm not complaining about pain, they've done their job. And so I went down this rabbit hole of studying traditional Chinese medicine, homey alcopy, naturopath, the phonchromaticin eventually, just interviewing people, learning from them, hiring clinicians, thinking that they were treating me, but I was actually trying to learn from them, studying the textbooks, taking courses, eventually I landed on genetics. So all that other stuff opened my eyes to, there is a path to finding the root cause. And the differences between all the other stuff and where genetics truly opened my eyes is the exact thing you said, which is the solution, the cause is also the solution. The cause is too much of something, not enough of something. That's also the solution. Remove the excess and add what's missing. That is health care, right?

10:46Now the question is, what are those things? It's different for all of us. And that's where the genome gave me my answer of what do I remove and what do I add? If I give you maybe two examples of myself, so the one big eye opener was, I believed, I started to believe that I was sick because my business partner, we were the same age, we lived on the same neighborhood, we drove to work together every day, we ate lunch together every day, we drove home together every day, we almost ate dinner together every day cause we worked late. The only time we weren't apart or together, so I would just say it was on the weekend, right? We literally lived five houses apart. Wow. Yeah, and he was fine and I was sick. So if I was doing something, why isn't he sick and you start to believe it? So the genome showed me this. There's a gene pathway called GSTM1, which is a driver of glutathione activity and glutathione being this master anti-oxidant of the body. GSTM1 directs glutathione in the gut. So it's like a first line of defense to isolate and delineate what is good and what is bad

11:49and remove the bad. This gene, there's a phenomenon called a copy number variation where it's not just a variant or mutation, but copy number variation literally means how many copies did you get of the gene? And for me, the answer is zero. So I literally don't have this genetic construction, what a human is supposed to do, I don't do. There's no direction of detoxification in my gut. In Canada where I live, there's certain chemicals that are used in grain type foods because we have long winters and we eat to store stuff. And so there's chemicals used to dry them for storage and there's chemicals used to reconstitute them to eat them. And if you ask the FDA and health Canada, they'll say those are safe. And the FDA and health Canada did not test me who's missing this gut gene. The assumption is I should be able to detoxify it, I can't. And so my gut lining was obliterated. It was completely permeable, leaky causing leaky gut, leaky brain leading to depression, all sorts of stuff, leading to autoimmune signals.

12:51Even though what I was doing was the right choice. Me and my business partner were eating a quote unquote Mediterranean diet. But I didn't know the hummus had those chemicals in it. Wow. Right? And I was actually trying to do something good. I was trying to eat clean and we would go to this level these restaurants like four or five times a week, I was like clean, clean, clean. But this chemical that even the restaurant toward didn't know about was breaking my gut. And my business partner had no issue because he didn't miss the gene that I was missing. So that's one of many things I discovered. And you start to learn that it doesn't have to be overwhelming. All this stuff, every podcast, every Instagram video, every TikTok, there's a new thing. And we want to do it all, right? It's really about the genome directing where are your breaks and what do you remove and what do you add? And I can go on and on about what I discovered myself, but that was a big one. That's really important. In fact, let's talk a little bit more about what your genes can tell you about your ability to detox. Because detox is like the big word these days.

13:52In fact, it's gotten to be kind of annoying to me, you know, it's just everywhere. It's in that you talk about the fact in your book, the DNA way that genetic sensitivity to environmental pollutants are really a big deal. And not everyone detoxes the same way. You just mentioned you were missing a gene about glutathione, which is, you know, your mastery antioxidant. So as a practical matter, when you hear all these things about detox, detox, detox, and all these people, I mean, there's a zillion products on the market. You know, we promote pure body extra, you know, the detox with zeolite, but maybe that's not the right thing. As a practical matter, could we use or could the general population use the DNA testing to know about their detoxification pathways and how to maximize them more efficiently? Absolutely. And I would say no surprise you landed on zeolite because it's one of the few things

14:53that seems to be universal where your genetics don't matter. It's going to work, right? And I know your hands on working on your clients, so you found the thing that actually works. It does work. Then there's many other tools that people use that require specific genetic variants for them to work. So let me give you a simple example. There was a lady I was working with in Hawaii who was two years into menopause, and she had brain frog and conic fatigue, which are pretty common symptoms of menopause. And her doctor told her to take some BHRT hormones, which is the right answer based on the symptom if you were willing to take hormones. So she asked me not in regards to the hormones, she had heard me on a podcast talking about if you get BHRT wrong, it can hurt you. You know, the maha movement just lifted the black walks warning. Great women have access to hormones now, but why was there a warning? You have scientists' researchers saying this will hurt you, but then you have scientists' researchers saying sorry, we should have not had a warning there. So in the gap in the middle, there's the bioindividual answer, which is we're not the same.

15:55We're not going to respond the same. And you can prove whatever you want to study based on who you study. So this lady, her question to me was, I heard you say that hormones can hurt you if you get it wrong, can you just check my DNA and tell me? When I looked at her DNA and I looked at the cascade of hormones, I said, I don't think what you're experiencing is a menopause symptom because the genetics of how you make hormones, clear hormones, it doesn't look like what you're describing. You shouldn't have this burden. Tell me what else you're doing. So she said, well, I moved from Australia to Hawaii. I said, oh, okay, well, you moved from this dry climate where she was in Australia to a moldy place called Hawaii. Maybe it's mold. And she said, no, I'll stop you there. I was aware of that. I have a function medicine doctor. I'm doing this detox. I'm dealing with the mold. I'm fine. I said, tell me about the detox. And she said, I'm taking this and this and this and I'm taking light pulse hormone gluteus ion. I said, okay, there's a gene called GSTT1, which is the primary driver of if you were to add gluteus ion, not the gluteus ion you're never makes, but if you're to add a dollop

16:57of it into your body, the instruction on what to do with it. Now if it's not being instructed, yes, it might bind some toxins, but it's also going to follow minerals, nutrients, and vitamins you need because it's not being told what to do. And this gene was missing in her genetic code. For a year and a half, she's been on this moldy talks and her brain fog and chronic fatigue was getting worse and worse and worse, not because of a menopause symptom, which, you know, anyone would agree. It sounds like menopause, her age where she's at symptoms that it adds up, right? Because she was taking something that was literally stripping her body of nutrition. And all we did was switch her to some precursors, anisinal cystine and lysine. And we said alter with some milk thistle, you know, maybe some zeolite here and there, right? And within four days, she said, my brain fog and chronic fatigue is gone. Wow. Right? So I'm not a miracle worker. I just invest in biology and say, I'm not even trying to solve the chronic fatigue and brain fog, just saying the things you add and the things you delete based on your genes, we have to get it right. And if you get it right, there's no gas work.

17:58There's no trial and error. And most of what they know, one side fits all. Yeah, for sure. I mean, that's an amazing story. And it kind of comes to the fact, I mean, it points out clearly why some people accumulate toxins and inflammation over time and other people don't. I mean, your own story tells that about your diet was clean and you were doing this exact same thing as your friend and your business partner every single day, you're getting sicker and he's living his life. Yeah. And so that is really, really an important reason for why people get, it should get their DNA testing and not just the testing, but understand the interpretation of that. You know, the DNA way in your book, I just love the way the book is written because you use yourself as a case study and you have your genes there. You talk about the genes and then you say, if you've got these patterns, these are all sorts of things you can do. So it's a very solution driven also to ask, in fact, after I read the book, I was like, where do I get this test? How do I do this?

18:59Because I want to know what's going on in my own body. You know, and you say that the DNA, the DNA way draws on analysis over 7,000 genetic profiles. As that research was going on and you were looking at more and more of those profiles, was there any particular patterns you found surprising as you were connecting the dots between the DNA and chronic, chronic conditions? Yes. That's an exciting thing that not many people ask about, by the way, but it's a really cool thing because we had a really unique study where three years, I tracked 7,000 people. And why? Because when I looked at the academic research, it didn't add up to me because I'm trying to get the personal end of one answer for each individual. Why am I being forced into this average evidence-based model, which is going to take that away? So I built my own research model and all those scientists around me saying that's not how you do research. I said, I don't care how you do research. I want to do it the way that leads me to the outcome I'm seeking that everybody gets their answer.

20:00And so I built my own study where I took 7,000 people that were mainly coming through clinics. The clinic couldn't figure that person out so they would send them to us. And we will use their genome not to solve the problem just to figure out where their biology is broken and give them the what you're moving, what you add and get them better. And we documented that 7 times, 7,000 times. And now we had from autism to fibromyalgia to breast cancer to libido issues. You name it. We worked on it and figured it out. So in that, we had this unique population of 7,000 people that are struggling. So when you look at big data, it looks very different than when you look at the data of people that are struggling. And the patterns keep emerging that are consistent. One big one. I didn't know this until I started doing the work. Nothing works if your nervous system is working. If you're stuck in fight or flight and you're trying to throw supplements for your hormones at it, your body's not even trying to recover them. Your body's stuck in a state of emergency.

21:00And it's reutilizing energy stores for what it thinks might be a punch in the face or a stab with a sword because of things you're on a battlefield. And so I'm interested in daily recovery and your gut health and your immune system, etc. and so on. So there's two pathways. TPH2, which drives serotonin production. And then there's 5HCTLPR, which drives the receptor that binds the serotonin. We think of serotonin as the happy hormone, right? It makes you feel good. The mechanism, if you actually study it, why does it affect somebody's mood so much? Serotonin allows your brain to prioritize stimulus. So if you're sitting doing anything, there's some people with really good serotonin genetics, meaning they make the right amount, they bind it that can very effectively filter and focus on what's important in the moment. So there's seeing reality and more of a macro big picture level, right? Then there's people that either don't make it properly or don't bind it properly and they can't filter. And they're experiencing the world at anywhere from 110 to 130% of reality. They have a heightened sense of what's really going

22:05on. And to them, that perception is real. They actually think that's what's happening. And to the other person, their perception is real. Now, if you're living in that world of every little detail is real, you're constantly annoyed, you're constantly frustrated, you're constantly disappointed, you turn into a helicopter mode and everybody else makes one of you, right? But there was a very real purpose of that. It was leadership. It was meant to be, I see what you don't see. Let me protect the tribe. But it wasn't supposed to be engaged all the time where it starts to get you into a cortisol addiction, constantly thinking, constantly doing, living in high functioning anxiety, fired your belly, can't stop because everything is a trigger, everything is a stimulus you can ignore, right? And so what we saw was if you look at big data, there's 5% of the general population is wired this way, wired for leadership. And sometimes they use it and they become a CEO. Then if you look at a patient population of 7,000 people that are sick, 65% of people are wired that way. It jumps from 5 to 65. But all of a sudden you have the blocker is their nervous system.

23:11Right? They're just stuck in fight or flight and they're so engaged that they're overdoing this stuff. They're doing too many things, saying yes to everything, overthinking, over-analysing, over-burdening themselves with things to do. And they fry their nervous system. So that's a big one. I would say the other big one, which has really driven my purpose, is everything around women's health. I didn't know going into this, how broken the system is for women. We know the system is broken, but it's so much worse for women. Women weren't included in medical research. So you go to a doctor, the toolkit assumes you're just a man without male genitals and everything else is the same. And you remove the complication of a 28-day hormone cycle from the study to make it easier to get things approved and all of a sudden women aren't included. And by the way, I did this work. Earlier on when I had the genital figured out, I actually started working with pharmaceutical companies thinking that that's what I was supposed to do. And I helped them with something called

24:11study design. So IBM had a partnership with a clinical research study, a company, so I should say, and I was helping them design studies. And my intention was to get a better study. But I realized what they were doing was filtering through the genome to make sure that whoever would make it fail was remote. So when you're selecting a jury, you can do the same thing in a study, study design. And they were using my genetic research to build that group. So anyways, way back to it, what I learned is that women's health is totally broken. And I couldn't understand why. You know, you look at dementia like 80% of dementia is women, 80% of autoimmunities in women, the list just keeps going on. The hormone metabolites, which we don't talk about medically, there's progesterone, turns it into testosterone, testosterone, aromatizes into estrogen, there's a gene that does that job so we don't how much estrogen you make. But after you make the estrogen, there's metabolites. And one of them is beneficial, what's called two hydroxy estrogen. Two of them

25:11are highly inflammatory, four hydroxy and 16 hydroxy. And genetically, you might be going down that path. And you're making something on the inside, you can be doing everything right. And you're making an inflammatory insult in your body. And it only matters so much because you live in such a hormone disrupting worlds. So it used to be okay to have a little bit of inflammation in the utero walls, who built it back better. So it's easier to get pregnant. Now it's like that profile plus all the estrogen limits. So same kind of numbers, where if you look at big data, about 5% of women are estrogen toxic, it's an anomaly. But when you look at my population, which is all these women that are struggling, it's 70%. Wow. Yeah. And so there's thing that's happening inside you in a context where the thing you're saying, what do you add? It's big added, whether you choose or not, hormone disruption is everywhere. Right. And so that's another thing we work heavily on. And women get a lot better. Well, you know, the the the Xenol estrogen problem

26:11is a really big deal. And it's really a big deal for everyone. And then compound it with your own intrinsic estrogens. And if you're if you have a genetic pathway, like you said, that you're not metabolizing it correctly, it just compounds over and over and over again, creates this whole thing of estrogen dominance. But conventional medicine is treating the estrogen dominance. Not by saying, why did you get estrogen dominance in the first place? Too much, adenoestrogens, wrong genetics, pushing your pathways in that direction. And that's why, you know, testing your DNA is so important. Well, you know, cash, we're going to have to take a quick station break here. Excuse me, because this is so interesting. And I know people are just eating this up because this is really, really state of the art stuff. So we're going to take a really quick break here. So hold that thought. We're going to take a short break to hear from our sponsors for America out loud. News. America out loud talk radio plays the 10 penny files on the I heart radio network Monday through Friday at 3 PM Eastern. If you've missed any of these great

27:15conversations and boy, we've had a lot of them. And I've read more than 150 books for you guys and summarized them and had great conversation with the authors since November. So you don't want to miss these conversations. And they just give you a little overview of what the whole book is about. You can find the 10 penny files on Spotify, P&Dora, Apple, iTunes, tune in. And on my platforms on drtempany.com, drtempany.substack.com and 10 penny walk with god.substack.com. We have a great message from our sponsors. Please listen closely. This is something that interests you. Please support our sponsors because they support us. We will be right back with more from with cash with cash. Shevecon about his book, The DNA Way Unlock the Secrets of your Gene story, Versed in these disease slow aging and achieves optimal wellness. The action plan to help you live your best life. We will be right back. People are doing everything right these days. They're eating clean and trying to avoid toxins and they're still not feeling well. That's because they no

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31:23Well, welcome back everyone. Let me tell you just a little bit more about today's guess. CashCon is a biotechnology entrepreneur and a co-founder of the DNA company. A company focused on applying functional genomics to personalized health and wellness. Raise in Vancouver, Canada, Mr. Conn began his career as an entrepreneur and business strategist advising from technology and finance to healthcare to create and to also to real estate. His path into genomics grew out of his own health challenges and an interest in understanding why people with similar lifestyles and exposures can experience very different outcomes. That interest eventually led him into merging field of functional genomics where he has focused on translating complex genetic information into practical insights involving nutrition, lifestyle, environment, aging and health. Through the DNA company, Cache has worked on making genomic information more

32:25understandable and accessible into the general public. He's also a two-time TEDx speaker, frequent guess and lecture on personalized health and genomics and longevity across the country. Cache, welcome so much to the 10-Pony files today. This is so interesting. Welcome back to the show. Weight management and nutrition are extensively covered in your book. The DNA in your book, the DNA way, which I really encourage everybody to pick up this because it's so informative. In the day of GLP1 drugs and fast fixes, what does your DNA research say about diets that work for one person but completely fail for another? Oh, there's so much because we can look at the actual food and the calories, but we can also look at the hidden blockers that people don't think about. So in terms of food and calories, we assume that we're all the same, but we're not. I can tell you if you should be a vegan or not. I can tell you if you should go

33:26do your carnivore diet or not. The genes make the enzymes to break down plant proteins and make you a successful vegan or known. The genes who actually effectively use fat as a source of fuel are known. There's some people that can use a keto diet to cure their diabetes and there's some people that a keto diet will cause diabetes. Wow. Yeah. And so we don't think of fat as a metabolic breaker, but it can be ultimately fat turns into glucose. So if you don't do a good job, you're going to cause metabolic dysfunction. But the calorie part is doable, very easy. There's the other stuff. The blockers, I think people are less aware of. For example, there's genes around satiety. And this is where the GLP's play a role, which is like they're trying to cut your appetite off and cause you to eat less, right? So do you actually need that? Is that this problem? So if you have a, for example, insulin resistance issue, there's a gene called TCF7L2, which determines the effectiveness of your insulin response. And some people are just born somewhat insulin resistant. Some people are born, you know, very like they're they can plow through

34:29sugar and eat their potatoes and they don't seem to have an insulin issue. Genetically, they just do a really good job. Now, the satiety side, there's a signal between the gut and the brain for the brains trying to survey when the gut is physically filling up to stop sending the the hunger signal, the Grelan horrible, which eventually just got to feel satisfied. There's a gene called FTO that is sort of surveying the environment, letting the brain know. And some people have a bad version of that gene. So there's a delayed signal. And that's the person that the plate is done. And now they're at the stove scooping out of the pot. And once they're done that, they're now looking at the dessert and they're ready to go. And they did, they can't stop the hunger. And the hunger has about a 15 to 20 minute delayed signal. Second, there's genetics around the palate. MC4R is the gene, which regulates the signal between the palate and the brain to understand when you're satisfied in terms of flavor diversity and texture diversity. And there's some people that they get full, but they don't get satisfied. And so they go to the pantry and they start grazing

35:31on the cookies and the chips and they're back and forth, right? So these two things were actually meant to be survival traits. When we see somebody who's kind of hormonally wired to be a warrior, their muscle tone, etc. Genetically, we can determine that. They're usually also wired this way, where if you had access to calories, you would pack it in because you're used to be on the battlefield. But you're also, you're also a genetic, these are the gene called UCP1, which regulates more metabolic rate. Those same people also have this propensity to succeeding with fasting. So they're genetically wired to have an ability to eat or sorry, go without food for a long time, but when they get it, pack in far more than they need the survival of the warrior. But in today's world, where your kitchen is packed and loaded, you don't need that anymore, right? And so the perception of the satisfaction is in there. And so the solutions are simple. Get some fiber and start signaling to your gut 20 minutes before. Get that FDOG activated. Create satiety of your palate. Have your meal, but have a little bit of cheese and snack and nuts and like the flavor diversity

36:32and like a French chakuna rembore. Why do they eat meat and cheese for dessert? Because it creates satisfaction, right? So the cognitive aspect, there's so many people that we're dealing with on weight that their mood and behavior genes are leading to food as a coping mechanism and they don't know. They actually feel a sense of hunger. And when you live in chronic anxiety, the body understands that high cortisol isn't good and it wants to get you out of that stress and that's another inflammatory insult. So it will create hunger as a source of comfort and you'll seek the comfort food. And so there's some people that don't regulate adrenaline well. So they're more prone to trauma. They're more prone to remembering what things feel like genetically. There's some people that don't do a good job of neuroplasticity genetically. They don't make BDF the primary fertilizer for neuroplasticity of the brain. And so they process things slower and so things have more weight and meaning to them than it has to somebody else. And so there's a bigger deal to stop. And so they react. There's some people who have some optimal dopamine receptors in their brain.

37:39They can't bind dopamine. So it's hard to feel pleasure. And so they keep going, going, and they become addicted. And there's some people that have really good dopamine receptors. They're very slow clearance in the last a long time. And so they end up binging. They're not addicted, but when they get what they want, they can't stop. And if you take all these pieces and they're there, then we'll top of weight management. You understand even your cognition can create a perception that you think you're doing everything right and you're not. Right? You know, it just popped into my mind while you were saying this is that every married couple should do this. Every every you know, or anybody that's in a serious relationship, both both both people should do this so that they understand each other better. Because if one person is looking at the world through one vision because of their genetics, and the other person has a different view because of their genetics, and you're constantly doing this because you think the other person's crazy or stupid or irrational or whatever. Once you understand that that's how they're made, then I think that you could come to a better understanding about what's for dinner, honey.

38:46I mean, everything can make such a big difference. So one of the co-founders of the business, my genetics around dopamine look like the DRD2 determines the density of the dopamine receptors. M-A-O breaks the dopamine down because once you're done with the reward seeking experience, you need to get rid of it and move on. Right? So DRD2 makes receptors. M-A-O breaks it down and comp clears it. So my DRD2 is the worst possible. So I experienced satisfaction at minus 70%. My M-A-O is the best possible. So I break it down before it's even finished. And my comp is also the best possible. So I get it out of the receptors really quickly. So I feel it way down here and it's gone like that. So I am wired for I can't get no satisfaction. And the academic answer to my profile is depression and addiction. And one of the things I suffered from was depression. But I'm neither addicted or depressed right now. But dopamine doesn't only power pleasure. It also powers reward achievement. So what this super power was meant to be is I have rewards seeking

39:50behavior entrepreneurial spirit. It's never enough. Now, my business partner, and that's part of what fixed me by the way, is I realized that the pressure was just a lack of challenge. My business partner had the opposite. He had the maximum dopamine receptors. And he had the slowest possible breakdown and the slowest possible clearance. So he lived in constant contentment. He lived and everything is good. And so we had go into a meeting and I would have this burning fire. Like here's the 10 things we got to do. And here's what they're doing. And he said, yeah, I get it. And within minutes, he's on Facebook talking to people and looking on vacations. And like, how are you possibly even thinking about this style? Like the deadline we have, he's like, yeah, don't worry, I'll get it done. Because there's no fire. There's no desire because he's already content. The satisfaction has already been had just from whatever's going on in daily life. So this led to a lot of friction because I thought he was a flake and he thought I was a psychopath. Right. And you can see what I'm saying in a relationship.

40:53And then we actually learned is we are two halves of the whole. The right answer was a little. And the right answer is let me go execute while he does the deep dives high quality work. I'm not good at the deep back. I'm not going to be in on something. I'm like, I'm always excited by the next shiny object. So for me, I can find the opportunity. I can execute on the plan, but he had to slow things down and do the high quality work on what actually matter. And now we started to work together wonderfully. Wow. I think that every marriage counselor in Canada and in the US should have access to to recommending this test. Let's talk a little bit about sleep because you talk about sleep a lot in your book. How does the DNA way or your personal DNA affect your sleep? And what can you do to change that? I would say it's once again, the anomalies that aren't the typical go-toes. Right. So for example, circadian rhythm, there are genes around your internal clock and how effectively your body understands what time it is. And so there's all these questions around all

41:55this stuff you can do around sleep hygiene. There's all the supplements, all the tools, all the biohacks, which one do you actually focus on? So for some people, it has to do with light and stress. The genetics of the internal clock are working for some people. And so they're much more sensitive to the cues of not getting daylight, not getting morning light, not getting grounding in the right signals of the earth at the right times and getting the wrong stimulus at night. So there's some people that get a glimpse of blue light and their sleep is ruined. And there's some people that can be working on their laptop right before they go to bed and they're fine. It's not perfect, but they don't have the major symptom that the other person has. So the genetics of circadian rhythm are very clear and what are you sensitive to is very clear. So sometimes that is a problem, sometimes it isn't. And you're wasting time solving the wrong problem. Then there's the genetics of we think of sleep as this one big thing, eight hours. Sleep is actually in two big halves. So you fall asleep. And in the first half, you're getting more into a deep sleep, which is you're dealing with the problems of yesterday,

42:59detoxification, tissue repair, muscle repair, all that stuff. So the most of your detoxification happens in that first three hours of your sleep. The glimps system starts pushing stuff down. The limb system activates. It's all happening at that time. You're cleaning up the mess. The second half of sleep is more preparation. Your body's getting ready for the next day. It starts making hormones, making the neurochemicals, getting ready. So in the first half, your body knows, I'm not supposed to wake up. We all get up in between these two. Someone must know, someone must don't know. For the second half, your body knows at some point, I'm supposed to get up out of bed and start my day. And for the first half, the signal to know it's time to sleep is our ancestors every night saw a fire in the dark. So the amber glow of fire in the dark is what triggers the binding of melatonin. You make it, but if you have a mountain, it's not going to get you to sleep. So again, the sensitivity to that is different for different people based on the genetics. The signal to wake up is sunlight piercing into your eyes and causing the binding of

44:01serotonin. And now that gets you out of bed. And then the adrenaline starts pumping cortisol is on and you're truly doing your job. So if you have the serotonin dysregulation I mentioned earlier, it also can affect the second half of sleep where a lot of people struggle. Like I fall asleep five, but something happens at 3 a.m. and it's not the same people. Quality's not the same. Because if you have bad serotonin genetics, your brain's ability to filter and focus on just the sunlight is not there. And it's like, how be touched, the blanket, the pillows, the little upbeat, it's too hot, it's too cold. All these things start to trigger your brain seeking is a time to get up. No, go back to sleep. Time to get up. No, go back to sleep. And it's completely disrupting that second half of sleep. And so the solutions are easy. Get a weighted blanket, convince your nervous system is safe. Keep the room cool. No light, no sound, separate blanket from the hubby. Make sure they're not coming on it and waking you up, right? Miter things that solve the right problem. Now, this same exact story, now that doesn't mean everybody go run

45:04out. And if you heard me say, you know, serotonin is the disruptor of your second half of sleep, now you're going to go assume that you would go do it. No, there are many things that will equal the same thing of the second half of my sleep. Doesn't work the same. So hormonally, some women, based on their hormones, you know, there's an interplay between the reproductive hormones and your metabolic hormones. There's an interplay between your metabolic hormones. Sorry, your reproductive hormones are neurochemicals, right? They all, there's like a cycle to connect. And there's so some women need glucose before going to sleep. And if they don't, they're going to give it a sort of drop. They're going to have this sort of glycemic event. There's a sugar drop and they wakes them up. And the simple answer is a spoonful of honey before you go to sleep, a slower release sugar that's not going to spike your insulin, that's going to prevent that drop that wakes you up. Now, I'm again, not saying everybody go out and start drinking honey before, but it's like we can determine which one it is if we hand your geno. And there's I can talk about headboard. Wow. Yeah. That's, you know, that's amazing. And I think that you, you know, you said

46:08at the beginning, excuse me at the beginning of our conversation here that there were about 100 genes that were important in the rest is kind of like noise, at least, at least noise so far that we haven't figured out what they do. And so does the, does your testing through the DNA company? Does it look at those 100 genes? So the DNA company looks at more than that now because it's trying to integrate the science into healthcare. So I'm building my own tests using the DNA companies lab to isolate the functional genes that matter. And that's going to be going live. I would say in like a month, right? Yeah. And so it's kind of a partnership with my ex company saying, you know, I built a lab, I built a tech, but here's the exact things that people need to know, right? And they're not doing that because they're trying to evolve into health. I'm saying, give me that and I'll do that, right? So that's, I built it. It's coming in like literally a bottom up. So, you know, everybody has heard about 23 and me and ancestry.com and them selling their DNA

47:15samples to Google and maybe even the Chinese. So I'm sure that a lot of people that are listening to this or thinking, man, I'd really like to get that test. But who owns that after they're done with them? Where does it go? So what happens to the, to your customers DNA samples after they've run the test? So this is actually a very real problem. If you're doing a DNA test, just assume your data is being sold. Why do I say that? It's a simple business consideration. DNA is the only test you'll do that you never need to do again. It's permanent. And so the business isn't so good. Blood work got microbiome. You have to keep doing so. It's a really good business. It's not that way with DNA. And so all these businesses became data selling companies. And where this really fails us, is their test? You're paying three, four, five hundred dollars for this test. But the data buyer is being paying five to twenty thousand dollars, depending what was found in the DNA. So who's the real customer in that equation? And who is the test designed for? You who need some insights or the

48:21guy that's paying you twenty thousand dollars to collect data? So it's designed for what they want to collect. And that's why a lot of these genetic tests are somewhat underwhelming. Like I didn't really learn much, right? Because they're not sequencing the genes that drive these functional insights. So I made it very clear to our lab that there's an incinerator in the lab. Literally, there's an oven. There's an incinerator. And as soon as the sample is uploaded to somebody's portal, the sample goes, it's thrown in a fire and destroyed. And I say that because even if I have terms that follow my beliefs around not selling data, what if the company gets sold? What if I'm gone? You know, something any who knows? So it's it's destroyed in a fire. So it's not even possible, right? And it's like, okay, the business doesn't work because now I have a DNA test sold once. But I work with people clinically. So I figure instead of selling their data, let me work with you all going clinically. And that's where the business comes from. Right? So that's a real assurance to the people that are listening to this that that they're your DNA when it goes to your company that it gets

49:28destroyed. It doesn't isn't saved in a file somewhere. It isn't sold to Google or to the Chinese or whatever biotech company is looking for DNA sort of things like that that they're the customer samples are destroyed, correct? The samples are destroyed. The data is another thing we do to safeguard it is usually a testing lab or a clinician will set up your portal into your account and upload it. So they know who you are. What I do is I send someone a test kit with a barcode and they create their own account. And I don't care if you use the alias, if you call yourself 10 penny number three, doesn't matter what you want to call yourself, right? You upload and create the portal yourself and only you have access to it. And the lab only sees a barcode. They don't know who it is. Right? You're just shipping back this thing with a barcode and the barcode is attached to the account. And so I did it that way to make sure people have sovereignty over their data, right? And that was a big deal. That is a really big deal. And it's a very big deal to the people that are listening to this.

50:31That's a real comfort to know that they can find out about their genetic makeup. And because it's the question that comes up all the time. You know, I'm going to do that DNA test and where does my DNA go from there? And now we know it goes into the incinerator and when they get testing there. So where do they get this test? Where can, you know, because where can people go like right after listening to this and go, I'm going to go buy that book because I want all the detail. And then I want to order this test. And where can they go to get that? So right now, my personal website, you know, what I'll do, which we didn't anticipate was let me create something for your audience that also gives them a little bit of a discount. We did that already. We did that. Our affiliate code is DRT. Okay, perfect. So let's do that. Yeah. So my website is cashconofficial.com. Say it's slower. Cash, cons, okay, a sh k h a n official.com. Okay, look for the DNA 360. That's going to allow you to

51:37buy the test that I built the DNA company called the DDA 360. But it's going to allow you to use it in my portal by personal clinical practice, which means if you ever want to work with me or my team, you can't. It has to be purchased through me so that I'm your provider, right? And I can work with you on your data. Otherwise, I can't. And then you can work with our colleagues here to figure out, we have programs and trainings and teachings and everything from like I need a phone call to, you know, I want to learn this and practice this. We all the way up to that, whatever somebody wants, right? Yeah. So cashconofficial.com. Forward slash the code that you have, right? DRT, which is our affiliate code that we use for a lot of our affiliates. Yeah. So forward slash DRT, that'll get you a discount. And I will make sure, because I told you we're relaunching under our new brand to sort of speak to the world now. I've been very quiet in my lab doing stuff and nobody knows. Even though we have many thousands of people in our clinic, it's just referrals from other clinics. I haven't publicly spoken about it, but that's coming

52:37next month. So the only thing that might happen is you might order the DNA 360, but by the time you get it, it might be under my new brand called Signal Health. So Signal Health is a launch on branding, because I believe health is all about signals from DNA to RNA to hormones to peptides. These are all the signals we don't understand. So you're you're finding us right during that transition, which is really cool. That's very cool, because this will be posted in a couple of weeks for the listeners from where, you know, you're listening to it now. It'll be ready probably to go from then. So cash, this has been phenomenal. And I love the book and I love all about this and I can't wait to get my own test, because I just really after reading all that, it's like, I'm sure that, you know, and I'm pretty healthy and I do things I eat clean, I do these different things, but I am sure that there are things that I can find out about myself that I could improve my improve everything that I'm doing. We've got about a minute and a half left in the show to hear today. What's what is it? If there was one idea that people could take away from your book, you're upcoming new business about the DNA testing, what do you think that idea? What do you think that should be?

53:42I think what I learned through all this is a chronic disease is optional. It's not in a given, it's not, I have Alzheimer's in my family. It's like, I have some broken biology that plus a habit could cause Alzheimer's, right? So the pace at which you age and whether or not you have disease is truly optional. If you understood what caused it. And so the functional path of using testing that is not blood work meant to prescribe a pill, but the root cause of what would cause the blood work to get altered in the first place, that's where we have to move to get health sovereignty back. And I've done it for myself, you know, I was very sick and I believe everybody can do the same thing. I think that is a phenomenal, hopeful message for everybody. And all you people out there that are have a marriage problems, if I wanted these for yourself and your spouse for Christmas, holidays are coming up, you know, go ahead and get that done. So thank you so much, Cash, for being with us here today. Thank you for all of your work. I'm really sincerely looking forward to getting my own test done. And with that, we're going to close out

54:44this for today and thank everybody for being here. Thank you for our listeners. We'll close with one of my favorite verses from the Bible. I close all my podcasts with whether it is live or pre-recorded, which is Romans 12 12, rejoice in hope, be patient in trouble and be persistent in prayer. So hang on to God, lean on to him for everything he will never let you down. We'll see you again here tomorrow or the next time on the 10 penny files. Have a great rest of your day everybody. Goodbye and God bless.