TROP2-Directed Antibody–Drug Conjugates in Non-Small-Cell Lung Cancer: Current Use in Clinical Practice and Future Directions

In this episode, Dr Matthew Gubens and Dr Helena Yu discuss the evolving role of TROP2-directed therapies in non-small-cell lung cancer, with a focus on how antibody–drug conjugates (ADCs) fit into current treatment strategies, including

• The mechanism of action and clinical trial outcomes of TROP2-directed ADCs like datopotamab deruxtecan and sacituzumab tirumotecan
• Use of these therapies in EGFR-mutant disease and how they fit into a changing treatment landscape
• Practical advice on associated adverse events and additional considerations,
• A look at future directions on the horizon, such as first-line studies and predictive biomarkers

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Presenters:

Matthew Gubens, MD, MS, FASCO​
Medical Director, Thoracic Medical Oncology​
University of California, San Francisco​
San Francisco, California

Helena Yu, MD​
Professor of Medicine​
Thoracic Oncology Service​
Memorial Sloan Kettering Cancer Center​
New York, New York

Link to full program:
https://bit.ly/41vAnfH

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