A medical question-and-answer guide for the curious reader. The authors, a novelist/screenwriter and an emergency room doctor, respectively, tackle a wide range of common, often humorous, medical queries that people might be too embarrassed to ask their doctors. Their collaboration stemmed from a chance meeting at a hospital where Goldberg was a medical advisor and Leyner a writer for a TV show. The content covers diverse topics from food and body oddities to drugs, alcohol, and medicine in popular culture, offering scientific explanations alongside anecdotal humor and personal exchanges between the authors.