Can THIS Plant Extract Activate GLP-1 Like Ozempic? (Sarah Kennedy) | Ep 427

Try Calocurb natural appetite support backed by clinical research. Get 10% off your first order at https://witsandweights.com/calocurb

—

Why does hunger sabotage weight loss even with perfect macros? Is appetite control really about discipline or hormone health?

Body recomp, weight loss, and building muscle get complicated fast when appetite refuses to cooperate. I dug into the real biology behind hunger with Sarah Kennedy, founder and CEO of Calocurb, to explore how the gut and brain regulate appetite through GLP-1 and other hormones tied to metabolism and nutrition. We unpacked why calorie deficits trigger powerful biological pushback, how bitter compounds can naturally influence appetite signals, and where these strategies fit alongside lifting weights, protein intake, and evidence-based nutrition.

This conversation reframes appetite as a physiological signal, not a personal failure, and shows how strength training, nutrition, and smart tools can work together. If you’re navigating fat loss, women’s fitness, or strength training over 40, this adds a missing layer most fitness podcasts ignore. It’s a practical lens on appetite control.

Today, you’ll learn all about:

0:00 – Why hunger overrides willpower
4:10 – Appetite hormones explained
8:45 – GLP-1 beyond weight loss drugs
13:30 – Bitter compounds and gut signaling
18:55 – Appetite control during fat loss
23:40 – Women’s hormones and cravings
28:20 – Using tools without dependency
33:10 – Long-term appetite strategies

Episode resources:

• Website: calocurb.com/witsandweights 
• Email: [email protected]
• Instagram: @calocurb 
• Facebook: @calocurbglobal
• Youtube: @calocurb 

💪 Join Eat More Lift Heavy - A 6-month coaching program for lifters over 40 who are done collecting information and ready to have real human coaches watch their data and know what to focus on each week.

📱 Get Fitness Lab (exclusive 20% off) - The #1 adaptive fitness and nutrition app. Daily coaching, workouts, and biofeedback-based guidance to help you build muscle and lose fat over 40.

👥 Join our Facebook community -  For adults over 40 who want to build muscle, lose fat, and stop following bad advice. Weekly Q&A threads, coaching insights, and real chat with other lifters.

👋 Ask a question or find Philip Pape on Instagram