The Scientist who helped bring back Direwolves! - Dr. Beth Shapiro

Dr. Beth Shapiro, Chief Science Officer at Colossal Biosciences, explains how her team brought back the dire wolf, what they've learned since, and how de-extinction tools are already helping endangered species like the red wolf. Hosted by Laurie McGraw on Inspiring Women. Beth Shapiro is a world-leading ancient DNA scientist, MacArthur Fellow, Rhodes Scholar, member of the National Academy of Sciences, and Professor of Ecology and Evolutionary Biology at UC Santa Cruz. She is the author of How to Clone a Mammoth (2015) and Life as We Made It (2021). IN THIS EPISODE - How Colossal de-extincts a species: ancient DNA, genome editing, cloning - Romulus, Remus and Khaleesi: life on a secure ecological preserve - Why the dire wolves will not be released into the wild - Red wolf clones and the Ghost Wolves Project with Bridgett vonHoldt - Bringing back the dodo to Mauritius, and the woolly mammoth and thylacine - New ancient DNA findings on cattle ancestry in North American bison - From broadcast journalism to Oxford and the new field of ancient DNA - Being a public face of science and changing your mind with new data KEY QUESTIONS ANSWERED What is de-extinction? Using DNA from fossils and remains to edit the genomes of living relatives so extinct traits return in living animals. Did Colossal bring back the dire wolf? Colossal announced three dire wolves in April 2025: Romulus and Remus (born October 1, 2024) and Khaleesi (born January 30, 2025). Will the dire wolves be released into the wild? No. Beth Shapiro says they will stay on a secure preserve because they would compete with struggling gray wolf populations. How does de-extinction help living species? The same cloning tools produced red wolf clones (Hope, Blaze, Cinder and Ash) to add genetic diversity to the most endangered wolf in North America. Why bring back the dodo? To restore ecosystems in Mauritius, remove invasive species, support ecotourism and protect endangered native species. Can dinosaurs be brought back? No. Ancient DNA does not survive that long. Jurassic Park author Michael Crichton was inspired by early ancient DNA research from Allan Wilson's lab at UC Berkeley. PEOPLE AND ORGANIZATIONS MENTIONED Colossal Biosciences · UC Santa Cruz · University of Oxford · University of Georgia · Smithsonian Tropical Research Institute · Princeton University · Alan Cooper · Allan Wilson · Bridgett vonHoldt · Michael Crichton ABOUT INSPIRING WOMEN Inspiring Women with Laurie McGraw features conversations with women leading in science, health, business and technology. #BethShapiro #ColossalBiosciences #DireWolf #DeExtinction #AncientDNA #Dodo #WoollyMammoth #RedWolf #InspiringWomen #LaurieMcGraw #WomenInScience