The Truth Behind Boxed Warnings

Boxed warnings can feel like a stop sign—but they don’t always reflect your personal risk. Dr. Nicholas Brownstone breaks down what these labels really mean, why they’re often added after approval, and how “association” (not proven causation) can still drive scary wording.

We also unpack class-wide warnings (like TB language on biologics and U.S. JAK inhibitor risks borrowed from older RA populations), why derm data can look very different, and how we counsel patients: put the warning in context, match it to your health profile, and monitor smartly—so fear doesn’t lead to undertreatment.